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Phenylalanine 

Other name(s):

a-amino-b-phenyl-propionic acid

Unsubstantiated claims

There may be benefits that have not yet been proven through research.

Phenylalanine is an essential amino acid. It is found in high-protein foods. It may improve memory and learning ability. It may enhance mood and alertness. It may help treat some types of depression. It’s been used to help treat schizophrenia and Parkinson disease.

Phenylalanine is used in some artificial sweeteners. It tends to decrease appetite. It’s been used to treat obesity.

It’s also claimed to boost pain tolerance in premenstrual syndrome (PMS) and migraine headaches.

Recommended intake

The FDA says that the supplement may be harmful.

Side effects, toxicity, and interactions

High levels of phenylalanine are linked with the genetic issue phenylketonuria. In infants with this issue, high levels of phenylalanine cause intellectual problems. It can also lead to seizures and delays in development.

Pregnant women with the condition who don’t avoid phenylalanine during pregnancy may give birth to a baby with signs of phenylketonuria.

Don't take this supplement if any of these are true:

  • You have phenylketonuria

  • You have melanoma (pigmented type)

  • You have tyrosinemia (type I or II)

  • You take monoamine oxidase inhibitors (MAOIs)

  • You are pregnant or breastfeeding

Online Medical Reviewer: Diane Horowitz MD
Online Medical Reviewer: Raymond Kent Turley BSN MSN RN
Online Medical Reviewer: Rita Sather RN
Date Last Reviewed: 3/1/2019
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Click here for more info on Coronavirus (COVID-19), vaccines, and visitor restrictions.
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Kettering Health Network (ketteringhealth.org)
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